Open AccessIntegrative Analysis of the Roles of lncRNAs and mRNAs in Itaconate-Mediated Protection Against Liver Ischemia-Reperfusion Injury in Mice
Author(s) -
Yanan Xu,
Zihao Li,
Shounan Lu,
Chaoqun Wang,
Shanjia Ke,
Xinglong Li,
Bing Yin,
Hongjun Yu,
Meng-Hua Zhou,
Shangha Pan,
Hongchi Jiang,
Yong Ma
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s327467
Subject(s) - messenger rna , reperfusion injury , liver injury , biology , rna , gene , long non coding rna , biochemistry , microbiology and biotechnology , pharmacology , ischemia , medicine
Itaconate is well known for its strong anti-inflammatory and antioxidant effect, but little is known about the potential role of long non-coding RNAs (lncRNAs) in the underlying mechanisms of hepatic ischemia-reperfusion (IR) injury. The aim of our study is to identify lncRNAs related to IR injury and itaconate-mediated protection and to demonstrate the mechanism by which itaconate acts in liver IR injury from the new perspective of lncRNAs.