Open AccessGold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress
Author(s) -
Ricardo A. Pinho,
Daniela Pacheco dos Santos Haupenthal,
Paulo Emílio Fauser,
Anand Thirupathi,
Paulo Cesar Silveira
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s327292
Subject(s) - oxidative stress , proinflammatory cytokine , reactive oxygen species , inflammation , regeneration (biology) , skeletal muscle , antioxidant , colloidal gold , medicine , web of science , inflammatory response , bioinformatics , chemistry , medline , biochemistry , biology , immunology , microbiology and biotechnology , nanoparticle , nanotechnology , materials science
Proinflammatory cytokines and reactive oxygen species are released after muscle damage, and although they are necessary for the muscle regeneration process, an excess of these substances leads to the destruction of biomolecules and impairment of the repair system. Several drugs have emerged in recent years to control the muscle inflammatory response, and studies have shown that gold nanoparticles (AuNPs) have anti-inflammatory and antioxidant properties. This review reveals the effects of AuNPs on the inflammatory and redox mechanisms of muscles. We assessed the results of several studies published in different journals over the last 20 years, with a focus on the effects of AuNPs on possible aspects of muscle regeneration or recovery, namely, inflammatory processes and redox system mechanisms. A systematic database search was conducted using PubMed, Medline, Bireme, Web of Science, and Google Scholar to identify peer-reviewed studies from the 2000s. Combinations of keywords related to muscle damage, regeneration or repair, AuNPs, oxidative stress, and antioxidants were used in the search. This review did not address other variables, such as specific diseases or other biological effects; however, these variables should be considered for a complete understanding of the effects of AuNPs on skeletal muscles.