Open AccessEmerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation
Author(s) -
Yongli Pan,
Qingzheng Jiao,
Wei Wei,
Tianyang Zheng,
Xinyu Yang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s327291
Subject(s) - neuroinflammation , inflammation , microglia , neuroscience , stroke (engine) , long non coding rna , microrna , mechanism (biology) , ischemic stroke , angiogenesis , bioinformatics , biology , medicine , ischemia , immunology , cancer research , downregulation and upregulation , gene , genetics , mechanical engineering , philosophy , epistemology , engineering
As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient's prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF-κB and ERK.