Open AccessNeuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats
Author(s) -
Cheng-Chia Tsai,
Cheng Feng,
Jacqueline C.C. Wu,
Chiung-Ju Wu,
Kuang-Yu Dai,
Shu-Mi Chen
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s325528
Subject(s) - rostral ventrolateral medulla , neuroinflammation , microglia , medicine , endocrinology , baroreflex , pharmacology , chemistry , blood pressure , heart rate , inflammation
Cadmium is a heavy metal and environmental toxicant known to act on the central cardiovascular regulatory mechanisms, and one of its brain targets is the rostral ventrolateral medulla (RVLM), a brainstem site that maintains blood pressure and sympathetic vasomotor tone. The present study assessed the hypothesis that cadmium elicits cardiovascular dysregulation by inducing neuroinflammation and microglial activation, two potential cellular mechanisms, in RVLM.