Open AccessAntibiotic Combined with Epitope-Specific Monoclonal Antibody Cocktail Protects Mice Against Bacteremia and Acute Pneumonia from Methicillin-Resistant Staphylococcus aureus Infection
Author(s) -
Lianli Duan,
Jinyong Zhang,
Zhi-Fu Chen,
Qiang Gou,
Qingshan Xiong,
Yue Yuan,
Huaiqi Jing,
Jiang Zhu,
Li Ni,
Yinan Zheng,
Zhiyong Liu,
Xiaokai Zhang,
Hao Zeng,
Quanming Zou,
Zhuo Zhao
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s325286
Subject(s) - bacteremia , staphylococcus aureus , microbiology and biotechnology , pneumonia , monoclonal antibody , methicillin resistant staphylococcus aureus , antibiotics , virology , epitope , medicine , staphylococcal infections , antibody , biology , immunology , bacteria , genetics
We previously reported that monoclonal antibody (mAb) cocktail improves survival in Staphylococcus aureus infection. In this study, we used acute pneumonia model and lethal sepsis model to investigate the efficacy of antibiotic combined with epitope-specific mAb cocktail in treating MRSA252 infection.