Open AccessClinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment
Author(s) -
Min Luo,
Yan Lin,
Rong Liang,
Yongqiang Li,
Lianying Ge
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s324336
Subject(s) - tumor microenvironment , hepatocellular carcinoma , medicine , oncology , immunohistochemistry , cancer , cancer research , tumor infiltrating lymphocytes , pathological , immunotherapy
The protein "human endogenous retrovirus H long terminal repeat-associating 2" (HHLA2), a member of the B7 family, has been linked to cancer progression and immune responses. However, its functional role in hepatocellular carcinoma (HCC) remains unknown.