Open AccessWNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M
Author(s) -
Petra Henning,
Sofia MovérareSkrtic,
Anna Westerlund,
Pedro Paulo Chaves de Souza,
Thais Floriano-Marcelino,
Karin Nilsson,
Maha El Shahawy,
Claes Ohlsson,
Ulf H. Lerner
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s323435
Subject(s) - oncostatin m , osteoclast , glycoprotein 130 , microbiology and biotechnology , chemistry , wnt signaling pathway , bone marrow , bone resorption , cytokine , signal transduction , medicine , endocrinology , receptor , biology , interleukin 6 , immunology , stat3 , biochemistry
Bone loss is often observed adjacent to inflammatory processes. The WNT signaling pathways have been implicated as novel regulators of both immune responses and bone metabolism. WNT16 is important for cortical bone mass by inhibiting osteoclast differentiation, and we have here investigated the regulation of WNT16 by several members of the pro-inflammatory gp130 cytokine family.