Open AccessProgranulin Protects Against Airway Remodeling Through the Modulation of Autophagy via HMGB1 Suppression in House Dust Mite-Induced Chronic Asthma
Author(s) -
Meixuan Liu,
Mengtian Shan,
Yunxuan Zhang,
Zhongliang Guo
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s322724
Subject(s) - hmgb1 , immunology , house dust mite , fibrosis , autophagy , downregulation and upregulation , airway , inflammation , gene knockdown , medicine , asthma , mucus , biology , allergy , pathology , cell culture , apoptosis , ecology , biochemistry , genetics , surgery , allergen , gene
Airway remodeling is an important feature of chronic asthma, and yet there are few effective therapeutic strategies. Progranulin (PGRN) has been shown to have lung protective functions, but the role of PGRN in asthmatic airway remodeling is unclear. We aim to explore the protective potential of PGRN on house dust mite (HDM)-induced airway remodeling and the underlying mechanisms.