Open AccessIncrease in Blood–Brain Barrier Permeability is Modulated by Tissue Kallikrein via Activation of Bradykinin B1 and B2 Receptor-Mediated Signaling
Author(s) -
Qin Zhang,
Juan Tan,
Li Wan,
Chao Chen,
Bin Wu,
Xijian Ke,
Ruiheng Wu,
Ran Xiao
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s322225
Subject(s) - bradykinin , tight junction , blood–brain barrier , receptor , bradykinin receptor , chemistry , nitric oxide , signal transduction , pharmacology , occludin , enos , nitric oxide synthase , microbiology and biotechnology , biology , medicine , endocrinology , biochemistry , central nervous system
Disruption of the blood-brain barrier (BBB) is a critical pathological feature after stroke. Although tissue kallikrein (TK) has used in the treatment of stroke in China, the role of TK in modulating BBB permeability is not clear.