Open AccessA Prospective Clinical Study on MGMT Protein Expression and the Effect of Gene Promoter Methylation on Sensitivity to Chemotherapeutics in Spinal Glioma
Author(s) -
Peng Sun,
Duojiao Fan,
Tao Fan,
Xin Li,
Xueling Qi,
Xue Zhao,
Qifei Gai
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s321790
Subject(s) - methylation , glioma , gene , dna methylation , gene expression , methyltransferase , cancer research , biology , microbiology and biotechnology , genetics
The present study discusses the O6-methylguanine-DNA methyltransferase (MGMT) protein expression of spinal glioma cells and the correlation between the sensitivity of promoter methylation of the MGMT gene to chemotherapy drugs, establishes a prediction method for the sensitivity of chemotherapy drugs on spinal gliomas, providing a theoretical basis for determining the best chemotherapy regimens for clinical patients after a spinal glioma operation.