Open AccessTranscriptome Analysis Reveals the Molecular Immunological Characteristics of Lesions in Patients with Halo Nevi When Compared to Stable Vitiligo, Normal Nevocytic Nevi and Cutaneous Melanoma
Author(s) -
Chun Pan,
Jingzhe Shang,
Haiqin Jiang,
Ying Shi,
Wenyue Zhang,
Jingshu Xiong,
Youming Mei,
Siyu Long,
Gai Ge,
Zhenzhen Wang,
Ziwei Wu,
Hongsheng Wang,
Aiping Wu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s321672
Subject(s) - vitiligo , immune system , immunology , melanoma , biology , transcriptome , innate immune system , gene , gene expression , cancer research , genetics
Given their similar appearance and histology, halo nevi (HN) were considered as a type of vitiligo. However, whether HN have stronger immune response than stable vitiligo (VL) remains unclear. In addition, the molecular alterations in HN compared with normal nevocytic nevi (NN) and primary cutaneous melanoma (MM) must be determined. This study aimed to systematically characterize the molecular immunological features of HN.