Open AccessResveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes
Author(s) -
Weimin Fan,
Shixian Chen,
Xianghui Wu,
Ji-Xiao Zhu,
Juan Li
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s320912
Subject(s) - mitophagy , resveratrol , pink1 , parkin , inflammation , chemistry , autophagy , arthritis , inflammasome , pharmacology , immunology , apoptosis , medicine , biochemistry , parkinson's disease , disease
Gouty arthritis (GA) is a common inflammatory disease with pain caused by the deposition of monosodium urate (MSU) crystals into joints and surrounding tissues. Resveratrol (Res), derived from grapes and peanuts and the traditional Chinese medicine (TCM) Reynoutria japonica for GA, acts against oxidation and inflammation. The present study aimed to investigate the therapeutic effect and mechanism of Res on GA.