Open AccessOral Limonite Supplement Ameliorates Glucose Intolerance in Diabetic and Obese Mice
Author(s) -
Akihiro Uchida,
Taro Yasuma,
Atsuro Takeshita,
Masaaki Toda,
Yuko Okano,
Kota Nishihama,
Cori. D’Alessandro-Gabazza,
Valeria Fridman D’Alessandro,
Chisa Inoue,
Takehiro Takagi,
Hiroyuki Mukaiyama,
Norio Takagi,
Katsumi Shimizu,
Yutaka Yano,
Esteban C. Gabazza
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s320451
Subject(s) - diabetes mellitus , limonite , proinflammatory cytokine , insulin resistance , microbiome , medicine , gut flora , endocrinology , biology , immunology , inflammation , bioinformatics , paleontology , hematite
Diabetes mellitus is a serious threat to public health worldwide. It causes a substantial economic burden, mental and physical disabilities, poor quality of life, and high mortality. Limonite is formed when iron-rich materials from the underground emerge and oxidized on the ground surface. It is currently used to purify contaminated water, absorption of irritant gases, and improve livestock breeding. Limonite can change the composition of environmental microbial communities. In the present study, we evaluated whether limonite can ameliorate glucose metabolism abnormalities by remodeling the gut microbiome.