Open AccessInterleukin -1β Promotes Lung Adenocarcinoma Growth and Invasion Through Promoting Glycolysis via p38 Pathway
Author(s) -
Qi Tan,
Limin Duan,
Qi Huang,
Wenjuan Chen,
Zimo Yang,
Jiangbin Chen,
Yang Jin
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s319433
Subject(s) - glycolysis , adenocarcinoma , lung , cancer research , chemistry , biology , microbiology and biotechnology , medicine , biochemistry , metabolism , cancer
There is a close relationship among inflammation, glycolysis, and tumors. The IL-1 family includes important inflammatory cytokines, among which IL-1β has been widely studied. In this study, we focused on the effect of IL-1β on glycolysis of lung adenocarcinoma (LUAD) cells in vivo and in vitro and explored its possible mechanisms.