Open AccessOverexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling
Author(s) -
Shan Lin,
Qinchang Chen,
Lishan Zhang,
Shaohua Ge,
Yuling Luo,
Wanmei He,
Caixia Xu,
Mian Zeng
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s319416
Subject(s) - mesenchymal stem cell , wnt signaling pathway , ards , lipopolysaccharide , cancer research , stem cell , bone marrow , apoptosis , endothelial stem cell , immunology , chemistry , pharmacology , microbiology and biotechnology , medicine , lung , signal transduction , biology , biochemistry , in vitro
Pulmonary vascular endothelial cell (EC) injury is recognized as one of the pathological factors of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Bone marrow mesenchymal stem cell (BMSC)-based cytotherapy has attracted substantial attention over recent years as a promising therapeutic approach for ALI/ARDS; however, its use remains limited due to inconsistent efficacy. Currently, gene modification techniques are widely applied to MSCs. In the present study, we aimed to investigate the effect of BMSCs overexpressing Homeobox B4 (HOXB4) on lipopolysaccharide (LPS)-induced EC injury.