Open AccessInhibition of MALT1 Alleviates Spinal Ischemia/Reperfusion Injury-Induced Neuroinflammation by Modulating Glial Endoplasmic Reticulum Stress in Rats
Author(s) -
Shutian Zhang,
Yinghua Yan,
Yongze Wang,
Zhaodong Sun,
Chengzhi Han,
Xiao Qian Qian,
Xiaorong Ren,
Yi Feng,
Jingwen Cai,
Chunmei Xia
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s319023
Subject(s) - spinal cord , neuroinflammation , astrocyte , microglia , medicine , spinal cord injury , reperfusion injury , evans blue , endoplasmic reticulum , glial fibrillary acidic protein , ischemia , pathology , central nervous system , immunology , endocrinology , microbiology and biotechnology , biology , inflammation , immunohistochemistry , psychiatry , disease
Glial activation and the disorders of cytokine secretion induced by endoplasmic reticulum stress (ERS) are crucial pathogenic processes in establishing ischemia/reperfusion (I/R) injury of the brain and spinal cord. This present study aimed to investigate the effects of mucous-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) on spinal cord ischemia/reperfusion (SCI/R) injury via regulating glial ERS.