Open AccessGamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells
Author(s) -
Alhaji Osman Smith,
Wen Ju,
Seyram Yao Adzraku,
Wenjing Lu,
Yuting Chen,
Jianlin Qiao,
Kailin Xu,
Lingyu Zeng
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s318812
Subject(s) - pyroptosis , inflammasome , microbiology and biotechnology , necroptosis , caspase 1 , endothelial stem cell , programmed cell death , cancer research , tumor necrosis factor alpha , cytokine , biology , immunology , apoptosis , medicine , chemistry , inflammation , in vitro , biochemistry
The extend to the clinical benefit of radiation therapy is the inability to eliminate only cancer cells and destroy normal cells such as microvascular endothelial in the vascular niche and turn induced-inflammasome signaling and cell death. These unfortunate injuries generated by ionizing radiation alter the therapeutic window and result in the re-occurrence of the malignancy. Therefore, we engaged in vitro studies by demonstrating radiation-induced inflammasome and cell death in endothelial cells.