Open AccessEfficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate
Author(s) -
Yuki Yamanashi,
Mika Ohmichi,
Yusuke Ohmichi,
Tatsunori Ikemoto,
YoungChang P. Arai,
Yohei Maruyama,
Shun Otsuka,
Shuichi Hirai,
Makoto Naito,
Masataka Deie
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s318540
Subject(s) - osteoarthritis , medicine , hyperalgesia , neuropathic pain , knee joint , brain derived neurotrophic factor , histopathology , endocrinology , joint pain , inflammation , neurotrophic factors , anesthesia , pathology , receptor , surgery , nociception , alternative medicine
To explore whether methotrexate (MTX) prevents joint destruction and improves pain-related behaviors in the acute phase of knee osteoarthritis (OA) induced by monosodium iodoacetate (MIA) in a rat model.