Open AccessIntegrating Bioinformatic Strategies with Real-World Data to Infer Distinctive Immunocyte Infiltration Landscape and Immunologically Relevant Transcriptome Fingerprints in Ossification of Ligamentum Flavum
Author(s) -
Baoliang Zhang,
Guanghui Chen,
Xi Chen,
Xiaoxi Yang,
Tianqi Fan,
Chuiguo Sun,
Zhongqiang Chen
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s318009
Subject(s) - immune system , transcriptome , biology , ossification , pathogenesis , infiltration (hvac) , gene , computational biology , immunology , genetics , gene expression , anatomy , physics , thermodynamics
Ossification of the ligamentum flavum (OLF) is a multifactorial disease characterized by an insidious and debilitating process of abnormal bone formation in ligamentum tissues. However, its definite pathogenesis has not been fully elucidated. Potential links between the immune system and various forms of heterotopic ossification have been discussed for many years, whereas no research investigated the immune effects on the initiation and development of OLF. Therefore, we attempt to shed light on this issue.