Open AccessMelatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease
Author(s) -
Ran Zheng,
Yang Ruan,
Yiqun Yan,
ZhiHao Lin,
NaiJia Xue,
Yaping Yan,
Jun Tian,
Xinzhen Yin,
Jiali Pu,
Baorong Zhang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s317672
Subject(s) - melatonin , inflammasome , mptp , neuroinflammation , microglia , dopaminergic , chemistry , neurotoxicity , pharmacology , endocrinology , microbiology and biotechnology , medicine , biology , immunology , inflammation , dopamine , toxicity
Inflammasome-induced neuroinflammation is a key contributor to the pathology of Parkinson's disease (PD). NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation has been implicated in PD in postmortem human PD brains, indicating it as a potential target for PD treatment. Melatonin, a multitasking molecule, has been found to have anti-inflammatory activities, mediated by silence information regulator 1 (SIRT1). However, whether and how melatonin is involved in inflammasome-induced neuroinflammation in PD pathogenesis remains unclear.