Open AccessA Novel Radiomics Nomogram for the Prediction of Secondary Loss of Response to Infliximab in Crohn’s Disease
Author(s) -
Yueying Chen,
Hanyang Li,
Jing Feng,
Shiteng Suo,
Qi Feng,
Jun Shen
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s314912
Subject(s) - nomogram , medicine , infliximab , radiomics , logistic regression , crohn's disease , lasso (programming language) , radiology , disease , world wide web , computer science
The prediction of the loss of response (LOR) to infliximab (IFX) is crucial for optimizing treatment strategies and shifting biologics. However, a secondary LOR is difficult to predict by endoscopy due to the intestinal stricture, perforation, and fistulas. This study aimed to develop and validate a radiomic nomogram for the prediction of secondary LOR to IFX in patients with Crohn's disease (CD).