Open AccessThrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway
Author(s) -
ChunHan Hou,
ChihHsin Tang,
Po-Chun Chen,
Ju-Fang Liu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s314747
Subject(s) - western blot , inflammation , small interfering rna , cancer research , osteoarthritis , signal transduction , angiogenesis , pi3k/akt/mtor pathway , protein kinase b , thrombospondin 1 , synovial membrane , immunology , cytokine , medicine , chemistry , transfection , microbiology and biotechnology , biology , pathology , cell culture , biochemistry , genetics , alternative medicine , gene
It is known that osteoarthritis (OA) pathogenesis involves inflammation that drives pathologic changes and that the matricellular protein, thrombospondin-2 (TSP2), is involved in angiogenesis, carcinogenesis, and inflammation. However, how TSP2 contributes to OA inflammatory processes is unclear.