Open AccessAssociations of Single Nucleotide Polymorphisms in IL-18 Gene with Plasmodium falciparum-Associated Malaria
Author(s) -
Alaa U AlRuwaisan,
Mashael R. Al-Anazi,
Mohammed I Shafeai,
Fuad H Rudiny,
Ali M. Motaen,
Saad M. Bin Dajem,
Hani Alothaid,
Kareem Morsy,
Saad Alkahtani,
Ahmed A. Al-Qahtani
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s314638
Subject(s) - parasitemia , single nucleotide polymorphism , plasmodium falciparum , malaria , haplotype , biology , immunology , snp , allele , genetics , genotype , gene
Interleukin-18 (IL-18) is a pro-inflammatory cytokine, reported to be involved in the initial immune responses against malaria. Genetic variations in the host are an important factor that influences the etiology of malaria at several disease levels. Polymorphisms within the IL-18 gene are associated with susceptibility and clinical outcome of several diseases.