Open AccessPADI6 Regulates Trophoblast Cell Migration-Invasion Through the Hippo/YAP1 Pathway in Hydatidiform Moles
Author(s) -
Bo Huang,
Yaping Zhao,
Lin Zhou,
Tingyu Gong,
Jiawen Feng,
Peilin Han,
Jiang Qian
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s313422
Subject(s) - trophoblast , yap1 , biology , microbiology and biotechnology , cytotrophoblast , placentation , gene knockdown , cell migration , cell growth , cell cycle , hippo signaling pathway , cell , apoptosis , signal transduction , placenta , genetics , transcription factor , fetus , gene , pregnancy
Peptidyl arginine deiminase, type VI (PADI6), a member of the subcortical maternal complex, plays an important role in oocyte growth and the development of fertilized oocytes. Human patients with PADI6 mutations can suffer from multiple reproductive deficiencies including hydatidiform moles and miscarriages. Recent studies have demonstrated that the Hippo signaling pathway plays a central role in the specification of the first cell fates and the maintenance of the human placental trophoblast epithelium. The present study aimed to verify the hypothesis that PADI6 regulates the biological functions of trophoblast cells by targeting YAP1 and to explore the mechanism by which PADI6 accomplishes this in trophoblast cells.