Open AccessSpermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis
Author(s) -
Hao Yuan,
Sixian Wu,
Yifeng Zhou,
Fang Peng
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s313179
Subject(s) - spermidine , inflammation , arthritis , macrophage polarization , macrophage , proinflammatory cytokine , synovial membrane , immunohistochemistry , chemistry , immunology , dexamethasone , medicine , endocrinology , biochemistry , in vitro , enzyme
Spermidine (SPD) is a naturally occurring polyamine. In this study, we examined the role and possible mechanism of SPD in collagen-induced arthritis (CIA) mice.