Open AccessLentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/β-Catenin Signaling Pathway
Author(s) -
Meng-Yuan Zhou,
Li Cai,
Xiaowen Feng,
Yu-rong Mu,
Bo Meng,
Fang-Yuan Liu,
Rong Li
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s312783
Subject(s) - wnt signaling pathway , cell growth , chemistry , cell cycle , apoptosis , gene silencing , cell migration , aquaporin 1 , flow cytometry , signal transduction , microbiology and biotechnology , cancer research , cell , biology , water channel , mechanical engineering , biochemistry , gene , engineering , inlet
Previous studies have confirmed the pathologic role of synovial aquaporin 1 (AQP1) in rheumatoid arthritis (RA), but its associations with the abnormal biologic behaviors of fibroblast-like synoviocytes (FLS) remain unclear. Herein, we examined the roles of AQP1 in the proliferation, migration and invasion of TNF-α-stimulated RA FLS (MH7A cells) and explored the underlying mechanisms.