Open AccessOverexpression of Neutrophil MMP-9 and HIF-1α May Contribute to the Finger-Like Projections Formation and Histo-Pathogenesis in Nasal Inverted Papilloma
Author(s) -
Tao Li,
Kai Sen Tan,
Yan Yi Tu,
Li Zhao,
Jing Liu,
Hsiao Hui Ong,
De Yun Wang,
Shi Li
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s312605
Subject(s) - nip , pathology , matrix metalloproteinase , epithelium , biology , pathogenesis , basement membrane , extracellular matrix , stroma , immunohistochemistry , blot , microbiology and biotechnology , medicine , biochemistry , computer science , gene , programming language
Nasal inverted papilloma (NIP) is defined based on its histological characteristic of inverted epithelium growth into the stroma. The inversion can result in epithelial growth in the underlying connective tissue stroma when the basement membrane completely separates from the epithelial layer. To date, such inversion mechanism underlying NIP's pathological phenomenon is unknown. Therefore, we hypothesized that mediators and soluble proteins released by neutrophils, the most predominant infiltrating cells in NIP, is vital in causing the epithelial changes and pathogenesis of NIP.