Open AccessLncRNA NEAT1 Promote Inflammatory Responses in Coronary Slow Flow Through Regulating miR-148b-3p/ICAM-1 Axis
Author(s) -
Qing Zhu,
Cuiting Zhao,
Yonghuai Wang,
Xinxin Li,
Yixue Xue,
Chao Ma
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s312583
Subject(s) - flow cytometry , tumor necrosis factor alpha , pathogenesis , reporter gene , icam 1 , apoptosis , blot , microbiology and biotechnology , luciferase , intracellular , medicine , cell , gene expression , cancer research , chemistry , cell adhesion molecule , pathology , biology , gene , immunology , transfection , biochemistry
Coronary slow flow (CSF) is an angiographic phenomenon characterized by delayed coronary opacification with normal or near-normal epicardial coronary arteries. The pathogenesis of CSF is closely related to inflammatory response. Accumulating evidence shows that long non-coding RNAs (lncRNAs) play an important role in cardiovascular disease. However, the mechanism underlying the influence of the lncRNA nuclear enriched abundant transcripts 1 (NEAT1) on CSF is still unknown.