Open AccessFNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population
Author(s) -
Kun Lin,
Linyuan Zhang,
Yishuai Wang,
Jinqing Li,
Yufen Xu,
Di Che,
Hanran Mai,
Hongyan Yu,
Lanyan Fu,
Bing Wei,
ZhiYong Jiang,
Lei Pi,
Xiaoqiong Gu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s311956
Subject(s) - kawasaki disease , medicine , gastroenterology , odds ratio , confidence interval , genotype , coronary artery disease , incidence (geometry) , aneurysm , artery , population , polymorphism (computer science) , coronary artery aneurysm , cardiology , surgery , gene , genetics , biology , physics , environmental health , optics
A large number of studies demonstrated that the key to the occurrence and development of Kawasaki disease (KD) is the over-activation of immune cells and the generation of various inflammatory factors, leading to the imbalance of the immune system. Recently, mutations in the FNDC1 gene have been shown to be associated with inflammatory responses. However, there have been no reports on the relationship between FNDC1 gene and KD so far.