Open AccessMolecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment
Author(s) -
Mena AlAni,
Noha Mousaad Elemam,
Ibrahim Yaseen Hachim,
Tom Kalathil Raju,
Jibran Sualeh Muhammad,
Mahmood Yaseen Hachim,
Riyad Bendardaf,
Azzam A. Maghazachi
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s310535
Subject(s) - experimental autoimmune encephalomyelitis , trastuzumab , immunology , multiple sclerosis , medicine , immunohistochemistry , timp1 , encephalomyelitis , biology , cancer research , breast cancer , gene expression , cancer , gene , biochemistry
Herceptin (trastuzumab) is an approved drug for treating HER2 + breast cancer patients, but its use for other diseases is not established. We sought to investigate the effects of Herceptin on ameliorating experimental autoimmune encephalomyelitis (EAE) and to examine its effects on the expression of various genes.