Open AccessGenetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and Adolescents
Author(s) -
Mohamed M Zedan,
Zeinab R. Attia,
Rania A. Abd El Azeem,
Thuraya M Mutawi,
Amora S El Shehawy,
Ashraf M. Bakr
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s309008
Subject(s) - single nucleotide polymorphism , genotype , stat4 , genotyping , allele , medicine , immunology , snp , biology , gene , genetics , stat3 , stat
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune inflammatory disease that is influenced by both genetic and environmental factors and associated with dysregulation of type I interferon (INF) response. This study aimed to investigate the effects of single nucleotide polymorphisms (SNPs) of the IFIH1, TNFAIP3, and STAT4 genes in the type I INF system on SLE risk in Egyptian children and adolescents.