Open AccessMesenchymal Stem Cell-Derived Exosomes Induced by IL-1β Attenuate Urethral Stricture Through Let-7c/PAK1/NF-κB-Regulated Macrophage M2 Polarization
Author(s) -
YeHui Chen,
Runan Dong,
Jian Hou,
Tingting Lin,
ShaoHao Chen,
Hang Chen,
Jiang Zhu,
Jia-Yin Chen,
ZhiBin Ke,
Fei Lin,
Xue-Yi Xue,
Yong Wei,
Ning Xu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s308405
Subject(s) - mesenchymal stem cell , urethral stricture , macrophage polarization , microrna , inflammation , cancer research , microbiology and biotechnology , stem cell , chemistry , in vitro , macrophage , pathology , biology , immunology , medicine , anatomy , urethra , biochemistry , gene
Urethral stricture is a clinical challenge for both patients and clinicians. Post-traumatic urethral stricture is associated with formation of scar tissue caused by excessive inflammation. The aim of this study is exploring potential therapeutic strategies for this condition.