Open AccessPyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Author(s) -
Nan Ji,
Zhongwen Qi,
Yueyao Wang,
Xinggang Yang,
Zhipeng Yan,
Meng Li,
Qihui Ge,
Junping Zhang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s308177
Subject(s) - pyroptosis , mechanism (biology) , disease , caspase 1 , autophagy , medicine , programmed cell death , cause of death , apoptosis , inflammasome , myocardial infarction , inflammation , immunology , biology , cardiology , philosophy , biochemistry , epistemology
Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.