Open AccessThe ACE2-Ang-(1‑7)-Mas Axis Modulates M1/M2 Macrophage Polarization to Relieve CLP-Induced Inflammation via TLR4-Mediated NF-кb and MAPK Pathways
Author(s) -
Hang Pan,
Wenhan Huang,
Zhongjie Wang,
Feifeng Ren,
Lei Luo,
Jun Zhou,
Ming Tian,
Lin Tang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s307801
Subject(s) - macrophage polarization , proinflammatory cytokine , inflammation , blot , tlr4 , m2 macrophage , macrophage , tumor necrosis factor alpha , mapk/erk pathway , chemistry , angiotensin ii , receptor , signal transduction , microbiology and biotechnology , endocrinology , immunology , biology , in vitro , biochemistry , gene
Angiotensin 1-7 [Ang-(1-7)] has been identified as an important anti-inflammatory and anti-fibrotic factor. This study determined how the ACE2-Ang-(1-7)-Mas axis affected M1/M2 macrophage polarization and thus contributed to anti-inflammatory processes in the cecal ligation and puncture (CLP)-induced inflammation model.