Open AccessDdb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis
Author(s) -
Yu Zong,
Haojie Shan,
Fuli Yin,
Xin Ma,
Chaolai Jiang,
Nan Wang,
Lihui Zhou,
Yiwei Lin,
Zubin Zhou,
Xiaowei Yu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s307316
Subject(s) - staphylococcus aureus , immune system , bone marrow , inflammation , innate immune system , immunology , osteomyelitis , tumor necrosis factor alpha , proinflammatory cytokine , biology , spleen , bacteria , genetics
Ddb1-cullin4-associated-factor 1 (DCAF1) is known to regulate protein ubiquitination, while the roles of DCAF1 in osteomyelitis remain unknown. This study aims to investigate the effects of DCAF1 deficiency in macrophages on osteomyelitis and elucidate the molecular mechanism.