Open AccessMulti-Organ Transcriptome Dynamics in a Mouse Model of Cecal Ligation and Puncture-Induced Polymicrobial Sepsis
Author(s) -
Izabela Rumieńczyk,
Maria Kulecka,
Jerzy Ostrowski,
Daniel Mar,
Karol Bomsztyk,
Stephen W. Standage,
Michał Mikula
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s307305
Subject(s) - sepsis , transcriptome , biology , immune system , multiple organ dysfunction syndrome , rna , ligation , organ dysfunction , immunology , kidney , gene expression , gene , genetics , microbiology and biotechnology
During sepsis, an excessive inflammatory immune reaction contributes to multi-organ dysfunction syndrome (MODS), a critical condition associated with high morbidity and mortality; however, the molecular mechanisms driving MODS remain elusive.