Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways | Zendy

Fuyu Jin | Zendy; Fei Geng | Zendy; Danfeng Xu | Zendy; Yaqian Li | Zendy; Tian Li | Zendy; Xinyu Yang | Zendy; Shupeng Liu | Zendy; Hui Zhang | Zendy; Zhongqiu Wei | Zendy; Shifeng Li | Zendy; Xuemin Gao | Zendy; Wenchen Cai | Zendy; Na Mao | Zendy; Yu Xue | Zendy; Heliang Liu | Zendy; Ying Sun | Zendy; Yang Fang | Zendy; Hong Xu | Zendy

Open Access

Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways

Author(s) -

Fuyu Jin,

Fei Geng,

Danfeng Xu,

Yaqian Li,

Tian Li,

Xinyu Yang,

Shupeng Liu,

Hui Zhang,

Zhongqiu Wei,

Shifeng Li,

Xuemin Gao,

Wenchen Cai,

Na Mao,

Yu Xue,

Heliang Liu,

Ying Sun,

Yang Fang,

Hong Xu

Publication year - 2021

Publication title -

journal of inflammation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.656

H-Index - 33

ISSN - 1178-7031

DOI - 10.2147/jir.s306883

Subject(s) - rankl , osteoclast , bone remodeling , tlr4 , chemistry , silicosis , lung , signal transduction , microbiology and biotechnology , receptor , endocrinology , medicine , pathology , activator (genetics) , biochemistry , biology

Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung macrophages and bone osteoclasts after silica inhalation in rats.

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