Open AccessA Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction
Author(s) -
Rana El Sabeh,
Mélanie Bonnet,
Katy Le Corf,
Kévin Lang,
Alain Kfoury,
Bassam Badran,
Nader Hussein,
François Virard,
Isabelle Treilleux,
Muriel Le Romancer,
Serge Lebecque,
Serge N. Manié,
Isabelle Coste,
Toufic Renno
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s306805
Subject(s) - estrogen receptor , estrogen , estrogen receptor alpha , receptor , microbiology and biotechnology , estrogen receptor beta , biology , cytokine , inflammation , signal transduction , chemistry , cancer research , medicine , endocrinology , immunology , biochemistry , genetics , cancer , breast cancer
Most Toll-like receptors and IL-1/IL-18 receptors activate a signaling cascade via the adaptor molecule MyD88, resulting in NF-κB activation and inflammatory cytokine and chemokine production. Females are less susceptible than males to inflammatory conditions, presumably due to protection by estrogen. The exact mechanism underlying this protection is unknown.