Open AccessChanges of Lipopolysaccharide-Induced Acute Kidney and Liver Injuries in Rats Based on Metabolomics Analysis
Author(s) -
Huan Gao,
Tao Yang,
Xuan Chen,
Yanqing Song
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s306789
Subject(s) - metabolomics , lipopolysaccharide , taurine , pharmacology , glutamine , hypotaurine , metabolite , kidney , metabolome , chemistry , glutathione , metabolic pathway , inflammation , acute kidney injury , biochemistry , metabolism , medicine , amino acid , chromatography , enzyme
The bacterial endotoxin lipopolysaccharide (LPS) was the classic inducer to establish many inflammatory disease models, especially multiple organ injury. Evidences indicated that the mechanism that causes inflammation response is not just related to cytokine release. The main aim of this study was to better elucidate the possible links between metabolic changes and the pathogenesis of LPS-induced acute liver and kidney in order to understand the mechanisms and screening therapeutic targets for developing early diagnostic strategies and treatments.