Open AccessGrape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway
Author(s) -
Wencui Wan,
Wei Zhu,
Yan Wu,
Yang Long,
Hongzhuo Liu,
Guangming Wan,
Jing Yu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s306456
Subject(s) - senescence , nad+ kinase , microbiology and biotechnology , retinal pigment epithelium , biology , nicotinamide phosphoribosyltransferase , retinal , biochemistry , enzyme
Retinal pigment epithelium (RPE) cellular senescence is an important process in degenerative retinal disorders. Grape seed proanthocyanidin extract (GSPE) alleviates senescence-related degenerative disorders; however, the potential effects of GSPE intake on RPE cellular senescence through regulating NAMPT/SIRT1/NLRP3 pathway remain unclear.