Open AccessVascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo
Author(s) -
Yuhan Chen,
Yuanyuan Chen,
Xueze Jiang,
Mengkun Shi,
Zhenwei Yang,
Zhiyong Chen,
Xuesheng Hua,
Jie Chen,
Yuepeng Wang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s305204
Subject(s) - neointima , vascular smooth muscle , microbiology and biotechnology , biology , fgf10 , fibroblast growth factor , autocrine signalling , downregulation and upregulation , endocrinology , cell culture , medicine , restenosis , receptor , biochemistry , genetics , smooth muscle , stent , gene
Activation of vascular adventitial fibroblasts (VAFs) upon vascular injury contributes greatly to the medial vascular smooth muscle cells (VSMCs) proliferation, migration and the subsequent neointima formation. A number of factors including fibroblast growth factors (FGFs) have been shown to control VSMC growth, proliferation and phenotypic switching, suggesting that they may function as paracrine signals for VAFs to modulate VSMCs functions. However, little is known about the signaling molecule(s) and its mechanism of action. This study is set to identify which and how FGF family members are involved in VAFs mediated vascular remodeling.