Open AccessExogenous Plant gma-miR-159a, Identified by miRNA Library Functional Screening, Ameliorated Hepatic Stellate Cell Activation and Inflammation via Inhibiting GSK-3β-Mediated Pathways
Author(s) -
Wen-Ying Yu,
Wei Cai,
Huazhong Ying,
Wenyou Zhang,
Huanhuan Zhang,
Chunjing Yu
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s304828
Subject(s) - hepatic stellate cell , mirbase , microrna , hepatic fibrosis , biology , fibrosis , inflammation , cancer research , microbiology and biotechnology , pharmacology , immunology , biochemistry , medicine , pathology , endocrinology , gene
Plant-derived exogenous microRNAs (miRNAs) regulate human physiological functions by blocking the translation of target mRNAs. Although several computational approaches have been developed to elucidate the interactions of cross-species miRNAs and their targets in mammals, the number of verified plant miRNAs is still limited, and the biological roles of most exogenous plant miRNAs remain unknown.