Open AccessThe Serum from Patients with Secondary Frozen Shoulder Following Rotator Cuff Repair Induces Shoulder Capsule Fibrosis and Promotes Macrophage Polarization and Fibroblast Activation
Author(s) -
Yaying Sun,
Jinrong Lin,
Zhiwen Luo,
Yuhan Zhang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s304555
Subject(s) - capsule , fibrosis , rotator cuff , inflammation , medicine , shoulders , fibroblast , macrophage polarization , macrophage , cohort , pathology , surgery , in vitro , biology , biochemistry , botany
Disorders with systematic inflammation were prognostic for secondary frozen shoulder (sFS) following rotator cuff repair (RCR); however, how systematic inflammation affects sFS remains unclear. The aim of this study was to observe the effect of pre-operative serum from patients with sFS and the serum from those without on shoulder capsule in mice, and on macrophages and fibroblasts in vitro.