Open AccessLack of Macrophage Migration Inhibitory Factor Reduces Susceptibility to Ventricular Arrhythmias During the Acute Phase of Myocardial Infarction
Author(s) -
Jingjing Lyu,
Jianming Huang,
Jin Wu,
Tao Yu,
Xin Wei,
Lei Qian
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s304553
Subject(s) - macrophage migration inhibitory factor , myocardial infarction , medicine , endocrinology , in vivo , tumor necrosis factor alpha , macrophage , inflammation , ex vivo , cytokine , in vitro , chemistry , biology , microbiology and biotechnology , biochemistry
Macrophages are involved in inflammatory responses and play a crucial role in aggravating ventricular arrhythmias (VAs) after myocardial infarction (MI). Macrophage migration inhibitory factor (MIF) participates in inflammatory responses during acute MI. In the present study, we hypothesized that knockout (KO) of MIF may prevent VAs during the acute phase of MI by inhibiting macrophage-derived pro-inflammatory mediators.