Open AccessHMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury
Author(s) -
Min Zhou,
Xiaogang Zhang,
Rui Tang,
Haiyan Liu,
Min Du,
Zhi Gao,
Zongshu Ji,
Haoshu Fang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s302967
Subject(s) - hmgb1 , foxp3 , il 2 receptor , spleen , tlr4 , lung , immunology , receptor , medicine , inflammation , chemistry , immune system , t cell
High-mobility group box-1 protein (HMGB1) serves as the prototypic damage-associated molecular pattern molecule, and TLR4 is considered a receptor for HMGB1. Regulatory T cells (Tregs) play a crucial role in infectious diseases. The role of HMGB1 in the modulation of Tregs is of great interest.