Open AccessPunicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis
Author(s) -
Mingcheng Huang,
Kunpeng Wu,
Shan Zeng,
Wenfen Liu,
Tianjiao Cui,
Zhiqing Chen,
Lian Yu Lin,
Dongying Chen,
Hui Ouyang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s302929
Subject(s) - inflammation , tumor necrosis factor alpha , arthritis , matrix metalloproteinase , proinflammatory cytokine , rheumatoid arthritis , immunology , iκbα , medicine , fibroblast , chemistry , western blot , cancer research , nf κb , in vitro , biochemistry , gene
The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural polyphenol extracted in pomegranate juice, which possesses antioxidant, anti-inflammatory and anti-tumor properties suggesting it may be a potent drug for RA therapy. However, there is paucity of information on its effect in RA.