Open AccessMiRNA-29c-3p Promotes Intestinal Inflammation via Targeting Leukemia Inhibitory Factor in Ulcerative Colitis
Author(s) -
Jian Guo,
Ruiya Zhang,
Yiqing Zhao,
Junping Wang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s302832
Subject(s) - colitis , downregulation and upregulation , ulcerative colitis , microrna , leukemia inhibitory factor , cancer research , inflammation , inflammatory bowel disease , transfection , proinflammatory cytokine , pathogenesis , chemistry , immunology , microbiology and biotechnology , biology , medicine , interleukin 6 , gene , biochemistry , disease
Dysregulation of micro-RNAs (miRNAs) is profoundly linked to inflammatory bowel diseases (IBD), but little is known about the specific biological functions of miRNAs in IBD. This study sought to elucidate the effect and the underlying target of miR-29c-3p in ulcerative colitis (UC).