Open AccessLXA4 Inhibits Lipopolysaccharide-Induced Inflammatory Cell Accumulation by Resident Macrophages in Mice
Author(s) -
Hongxia Mei,
Yong Yang,
Haoran Xu,
ShuYang Xiang,
Qian Yang,
Hongyu Ma,
Shudong Jin,
Qian Wang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s301292
Subject(s) - cxcl2 , lipopolysaccharide , macrophage , tumor necrosis factor alpha , ards , monocyte , inflammation , immunology , macrophage activating factor , lipoxin , ccl2 , medicine , pharmacology , biology , chemokine , lung , in vitro , biochemistry , chemokine receptor
Alveolar macrophages that regulate the inflammatory response in lungs are the main target cell for the treatment of inflammatory pulmonary pathologies, such as acute respiratory distress syndrome (ARDS). Yolk sac derived alveolar resident macrophages play an important role in the pulmonary inflammatory response. With regards to anti-inflammatory actions, lipoxin A4 (LXA4) has been identified as an inflammatory "braking signal".