Open AccessPoor Clearance of Free Hemoglobin Due to Lower Active Haptoglobin Availability is Associated with Osteoarthritis Inflammation
Author(s) -
A. Sarkar,
Monu,
Vijay Kumar,
Rajesh Malhotra,
Hemant Pandit,
Elena Jones,
Frédérique Ponchel,
S. N. Biswas
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s300801
Subject(s) - haptoglobin , osteoarthritis , proteome , inflammation , hemoglobin , pathophysiology , autoantibody , western blot , medicine , blood proteins , hemopexin , immunology , chemistry , pathology , antibody , biochemistry , heme , alternative medicine , gene , enzyme
Circulating plasma proteins play an important role in various diseases, and analysis of the plasma proteome has led to the discovery of various disease biomarkers. Osteoarthritis (OA) is the most common chronic joint disease, mostly affecting people of older age. OA typically starts as a focal disease (in a single compartment, typically treated with unicompartmental knee replacement), and then progresses to the other compartments (if not treated in time, typically treated with total knee replacement). For this, identification of differential proteins was carried out in plasma samples of OA cases and compared with healthy controls. The aim of this study was to identify circulatory differentially expressed proteins (DEPs) in knee-OA patients undergoing total knee replacement or unicompartmental knee replacement compared to healthy controls and assess their role, in order to have better understanding of the etiology behind OA pathophysiology.