Open AccessMethanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis
Author(s) -
Faris Alrumaihi,
Masood Alam Khan,
Khaled S. Allemailem,
Mohammed A Alsahli,
Ahmad Almatroudi,
Hina Younus,
Sultan A. Alsuhaibani,
Mohammad Algahtani,
Arif Khan
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s300025
Subject(s) - apoptosis , cytotoxicity , trigonella , mcf 7 , cancer , breast cancer , pharmacology , mitotic catastrophe , flow cytometry , cancer cell , cancer research , chemistry , toxicity , programmed cell death , medicine , traditional medicine , immunology , in vitro , biochemistry , human breast
The plant Trigonella foenum-graecum , well-known as fenugreek, has been shown to control type-2 diabetes, the level of cholesterol, inflammation of wounds, disorders related to gastrointestinal tracts, and cancer as well. The present study aimed to evaluate the anti-cancer potential of methanolic fenugreek seed extract (FSE) and its possible molecular mechanism of action in breast cancer cells.